Cannabis-based aerosol-generating substrates, articles, systems, and methods with controlled cannabinoid delivery

A method of manufacturing an aerosol-generating substrate, the method comprising:

• subjecting a cannabis material to mechanical comminution to form particles having a D90 of a particle size distribution of 1 μm to 150 μm;
• reducing, by freeze-drying, a moisture content of the comminuted cannabis material to 2% to 5% by weight;
• charging 25% to 90% by weight of cannabis material particles, 0% to 60% by weight of a skeletal material, 1% to 10% by weight of a binder, and 3% to 10% by weight of a flavoring into a low-temperature mixing apparatus and mixing the same uniformly;
• and
• extruding the mixture through an extruder to form an aerosol-generating substrate having a predetermined geometry, the aerosol-generating substrate having an interior comprising a plurality of air channels, each of the air channels extending to at least one end of the aerosol-generating substrate in a longitudinal direction.

An aerosol-generating system, comprising:

• an aerosol-generating article comprising an aerosol-generating substrate, the aerosol-generating substrate comprising cannabis;
• and
• an aerosol-generating device configured to heat the aerosol-generating substrate to generate an aerosol;
• wherein, during heating, under a puffing regime according to a Health Canada Intense smoking regime, a mass of aerosol per puff is in a range of 3 mg to 10 mg, and a cannabinoid content per puff is in a range of 1.5 mg to 10 mg.