Double encapsulated nanocomposite for staged delivery of active ingredient(s), and a method of producing thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsRathna Venkata Naga GUNDLOORI, Tripurari Rao GAUTAM
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Abstract
The present invention relates to a carrier system for agrochemicals. Specifically, the present invention relates to a carrier system based on nanocomposites comprising double encapsulated nanocomposite composition for staged delivery of a growth stimulant for a weed and a herbicide for controlling the same. The encapsulation of active ingredients is designed in such a way that growth stimulant is released initially to induce the germination of the weed and then, the herbicides to kill them during the emergence. The present invention also relates to a method of producing the double encapsulated nanocomposite granules and uses thereof.
Claims14
A double encapsulated nanocomposite composition, comprising:
- i. a cross-linked ethyl cellulose (EC) nanoparticles,
- ii. 1st active ingredient,
- iii. cross-linked gelatin-nanoclay nanofibers, and
- iv. 2nd active ingredient;
- wherein the cross-linked EC nanoparticles and 1st active ingredient are combined to prepare 1st active ingredient-loaded cross-linked EC nanoparticles as 1st encapsulation,
- wherein the cross-linked gelatin-nanoclay nanofibers and 2nd active ingredient are combined to prepare 2nd active ingredient-loaded cross-linked gelatin-nanoclay nanofibers, and
- wherein the 1st active ingredient-loaded cross-linked EC nanoparticles is within a mat comprising of said 2nd active ingredient-loaded cross-linked gelatin-nanoclay nanofiber forming said double encapsulated nanocomposite composition.
A process of preparation of a double encapsulated nanocomposite composition, the process comprising:
- a) preparing ethyl cellulose (EC) nanoparticles by treating ethyl cellulose (EC) with polyvinyl alcohol (PVA) as stabilizer in presence of 1st active ingredient, followed by cross-linking the nanoparticles using CaCl2 to obtain 1st encapsulation of active ingredient as 1st active ingredient-loaded cross-linked EC nanoparticles;
- b) mixing 1st active ingredient-loaded cross-linked EC nanoparticles in the solution of gelatin-nanoclay to obtain 1st active ingredient loaded double encapsulated nanofibers;
- c) mixing the 2nd active ingredient and 1st active ingredient loaded crosslinked EC nanoparticles in the solution of gelatin-nanoclay to obtain double encapsulated nanofibers;
- d) preparing cross-linked gelatin-nanoclay nanofibers by treating nanofibers with a specific amount of crosslinkers to obtain the final double encapsulated nanocomposite composition;
- wherein the specific amount of crosslinkers is 0.05-50% w/w with respect to the gelatin.
Dependencies are inferred from the claim text.