Ion Guide Bandpass Filter with Dynamic Window Optimization
AssigneeDH Technologies Development Pte. Ltd.
InventorsDavid Michael COX, Yang KANG
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Abstract
In one aspect, a method of performing MRM mass spectrometry is disclosed, which includes identifying a plurality of precursor ions expected to arrive at an ion guide positioned upstream of a mass filter during a predefined time period subsequent to MRM analysis of a current precursor ion selected by the mass filter, determining a bandpass window for application to said ion guide based on a maximum m/z difference between an m/z of the current precursor ion and m/z ratios of said plurality of precursor ions to be analyzed in said subsequent time period, and configuring the ion guide to provide said bandpass window.
Claims15
A method of performing MRM mass spectrometry, comprising:
- identifying a plurality of precursor ions expected to arrive at an ion guide positioned upstream of a mass filter during a predefined time period subsequent to MRM analysis of a current precursor ion selected by the mass filter,
- determining a bandpass window for application to said ion guide based on a maximum m/z difference between an m/z of the current precursor ion and m/z ratios of said plurality of precursor ions to be analyzed in said subsequent time period, and
- configuring the ion guide to provide said bandpass window.
A mass spectrometer, comprising:
- an ion guide configured to receive a plurality of ions, said ion guide having a plurality of rods arranged in a multipole configuration and configured for application of one or more RF voltages thereto for generating a radial confining electromagnetic field and having a plurality of auxiliary electrodes interspersed between said plurality of rods and configured for application of one or more DC voltages thereto for generating a passband window for controlling transmission of ions through the ion guide,
- a mass filter positioned downstream of the ion guide for selecting precursor ions for MRM analysis,
- a controller in communication with the ion guide and the mass filter,
- wherein said controller is configured to adjust the bandpass of the ion guide based on a maximum m/z difference between an m/z of a current precursor ion under MRM analysis and m/z ratios of a plurality of precursor ions to be analyzed in a predefined time period subsequent to analysis of the current precursor ion.
Dependencies are inferred from the claim text.