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US 2026/0202415 A1Published application
Methods and compositions for protein sequencing
AssigneeQuantum-Si Incorporated
InventorsBrian Reed, Jeremy Lackey, Haidong Huang
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Abstract
Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
Claims24
-283. (canceled)
A method of polypeptide sequencing, the method comprising:
- (a) detecting a first series of signal pulses indicative of association of a first set of one or more amino acid recognition molecules with a first amino acid at a terminus of a polypeptide;
- (b) removing the first amino acid from the terminus of the polypeptide, wherein a second amino acid is exposed at the terminus of the polypeptide;
- and
- (c) detecting a second series of signal pulses indicative of association of a second set of one or more amino acid recognition molecules with the second amino acid at the terminus of the polypeptide;
- and
- (d) identifying the first amino acid based at least in part on the second series of signal pulses.
3 more elements
Dependencies are inferred from the claim text.