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AssigneeRheinisch-Westfälische Technische Hochschule (RWTH) Aachen
InventorsRafael KRAMANN, Konrad HOEFT, Lars Leonard KOCH
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The present invention relates to the role of ADAMTS12 protein (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 12 protein) in the development of chronic kidney disease, in particular progressive chronic kidney disease and renal fibrosis. In particular, the present invention relates to methods for identifying compounds that bind to the ADAMTS12 protein and to the use of ADAMTS12 protein for screening and identifying ADAMTS12-interacting and ADAMTS12-inhibiting compounds. The present invention further relates to pharmaceutical compositions for use in the treatment of kidney diseases, in particular pharmaceutical compositions comprising active agents that bind to and/or inhibit the ADAMTS12 protein.
A method for reducing the expression and/or secretion of extracellular matrix (ECM) proteins by a given cell, and/or for inhibiting the migration of fibroblasts, wherein the method comprises at least one step selected from the group consisting of
A method for identifying an active agent that binds to the ADAMTS12 protein (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 12 protein) or a fragment thereof, and/or inhibits or reduces the activity of the ADAMTS12 protein, or a fragment thereof, comprising at least the following steps:
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An active agent which binds to the ADAMTS12 protein (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 12 protein) or a fragment thereof, and/or inhibits or reduces the activity of the ADAMTS12 protein, or a fragment thereof, and/or promotes the degradation of the ADAMTS12 protein.
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A method for treating or preventing chronic kidney disease and/or heart disease, wherein the method comprises administering to a human or animal subject a therapeutically effective dose of an active agent that binds to and/or inhibits the ADAMTS12 protein.
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Dependencies are inferred from the claim text.