Methods of Screening and Compounds
AssigneePxd, Inc.
InventorDavid Langton
Life of this patent
Estimating the term…
Abstract
Methods of screening a subject to determine whether or not they are at risk of having an adverse reaction to metal debris (ARMD), also known as adverse local tissue reaction (ALTR), methods of screening compounds for use in preventing or ameliorating such an adverse response and compounds for use in treating a subject.
Claims19
A method of screening a subject to determine the likelihood of adverse response to metal debris (ARMD) or adverse local tissue reaction (ALTR), said method comprising the steps of:
- determining whether the subject has one or more of the following markers associated with an adverse response wherein the marker comprises one or more from the following table:
- SNP
- Gene
- Protein
- GSA-rs35269015
- MCC
- relating to the function and/or
- expression of MCC
- GSA-rs68164453
- Intragenic
- relating to the function and/or
- expression of LOC105374976
- GSA-rs10985824
- u/s RABGAP1
- relating to the function and/or
- expression of RABGAP1
- GSA-rs190079656
- ADAMTSL3
- relating to the function and/or
- expression of the ADAMTSL3
- GSA-rs117972780
- OR1L4
- relating to the function and/or
- expression of OR1L4
- GSA-rs45539538
- CYP24A1
- relating to the function and/or
- expression of CYP24A1
- GSA-rs79208627
- LOC101927964
- relating to the function and/or
- expression of LOC101927964
- GSA-rs976508
- PIGN
- relating to the function and/or
- expression of PIGN
- GSA-rs76147841
- GABBR2
- relating to the function and/or
- expression of GABBR2
- GSA-rs1930426
- u/s RABGAP1
- relating to the function and/or
- expression of GABBR2
- rs56177975
- d/s TGFB2
- relating to the function and/or
- expression of TGF2
- rs1392779
- between INPP4B
- (relating to the function and/or
- and IL5
- expression of INPP4B and IL5
- rs13145571
- SULT1E1
- relating to the function and/or
- expression of SULT1E1
- rs10790129
- intergenic
- rs2304968
- SLFN12L
- relating to the function and/or
- expression of SLFN12L
- rs4798850
- RAB31
- relating to the function and/or
- expression of RAB31
- rs57039293
- UMAD1
- Relating to the function and/or
- expression of UMAD1
- rs79000696
- CYP24A1
- Relating to the function and/or
- expression of CYP24A1
- and optionally,
- HLA-DRB1*01, DRB1*04, DRB1*10 (18, 19) DQA1*05:
- 01/DQB1*02:01 HLA-DRB1*07, HLA-DRB1*0103, HLA-DRB1*04 and HLA-DRB3*0301. (20),
- wherein the presence of one or more of the markers associated with an adverse response is indicative of an increased likelihood of an adverse response in a subject.
A method of screening a compound or a therapeutic agent for use in the treatment of adverse reaction to metal debris (ARMD) and/or adverse local tissue reaction (ALTR) response to an implant or use in preventing or ameliorating the likelihood of ARMD or ALTR in a subject, said method comprising the steps of contacting the compound or therapeutic agent with albumin-cobalt metalloprotein to determine if binding occurs or determining whether the compound or therapeutic agent interferes with an MHC mediated immune response.
13-14. (canceled)
A kit or device for screening a subject to determine the likelihood of adverse response to metal debris (ARMD) or adverse local tissue reaction (ALTR), comprising:
- reagents or means for determining whether an individual has any of the following SNPs:
- rs17090828, GSA-rs1930426, GSA-rs79208627, GSA-rs45539538, GSA-rs76147841, GSA-rs117972780, rs4798850, rs11974031, rs9301947, GSA.rs17716559 PIGN, rs12248205, rs1392779, rs13145571, GSA-rs35269015, GSA-rs68164453, GSA-rs10985824, GSA-rs190079656, GSA-rs76147841, GSA-rs117972780, GSA-rs79208627, GSA-rs976508, GSA-rs35269015,
- GSA-rs76147841, GSA-rs1930426 and GSA-rs45539538;
- and optionally reagents or means for determining vitamin D status of a subject;
- and directions for determining the likelihood of adverse response to metal debris (ARMD) or adverse local tissue reaction (ALTR) based on the presence of any of the SNPs and optionally, the vitamin D status of the subject.
(canceled)
Dependencies are inferred from the claim text.