High performance fluorescence imaging module for genomic testing assay
AssigneeElement Biosciences, Inc.
InventorsSteve Xiangling CHEN, Minghao GUO, Michael PREVITE, Chunhong ZHOU, Derek FULLER
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Abstract
Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications.
Claims26
-20. (canceled)
A sequencing system for sequencing nucleic acids, comprising:
- an optical system comprising:
- an excitation energy source configured to illuminate one or more samples immobilized on a flow cell, and
- an objective lens having a field-of-view (FOV) of greater than 5 mm2;
- and
- at least one image sensor configured to acquire flow cell images of the one or more samples at a plurality of sample planes of the flow cell.
Dependencies are inferred from the claim text.