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US 2026/0201455 A1Published application
Methods and devices for detection and acquisition of biomarkers
AssigneesMiNDERA Corporation, The Scripps Research Institute
InventorsTahir A. MAHMOOD, Tobin J. DICKERSON, Nadir A. MAHMOOD, Petr CAPEK
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Abstract
The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).
Claims21
(canceled)
A method for mRNA extraction from a subject, comprising:
- contacting a device with a skin of the subject, wherein the device comprises a plurality of microneedles and a polynucleotide probe attached to a microneedle of the plurality of microneedles, wherein a center-to-center distance between two adjacent microneedles of the plurality of microneedles is greater than 200 μm and less than 1000 μm, and wherein the polynucleotide probe hybridizes to an mRNA in the skin of the subject;
- and
- removing the device having the mRNA hybridized to the polynucleotide probe from the skin of the subject, thereby extracting the mRNA from the subject.
Dependencies are inferred from the claim text.