Methods of modulating immune function in plants
AssigneeResurrect Bio Ltd
InventorsSophien Kamoun, Lida Derevnina, Mauricio Contreras
Life of this patent
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Abstract
The present invention relates to genetically altered plants, parts thereof and plant cells that comprise one or more mutations in one or more NLR proteins, such as the helper NLR proteins, NRC2 and/or NRC3, as well as methods of providing or improving immunity of a plant to a pathogen or pest by introducing one or more mutations into one or more NLR genes.
Claims32
A genetically altered plant, plant part thereof or plant cell, wherein the plant, part thereof or plant cell comprises at least one mutation in at least one nucleic acid sequence encoding a nucleotide-binding domain and leucine-rich repeat-containing (NLR) protein, wherein the NLR protein comprises a HD1 domain, and wherein the at least one mutation is a mutation of one or more amino acids in an N-terminal portion of the HD1 domain.
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A genetically altered plant, plant part thereof or plant cell, wherein the plant, part thereof or plant cell expresses a nucleic acid construct comprising a nucleic acid sequence encoding a mutated NLR protein, wherein the NLR protein comprises a HD1 domain, and wherein the NLR protein comprises a mutation of one or more amino acids in an N-terminal portion of the HD1 domain.
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A method of providing or improving pathogen resistance in a plant, the method comprising introducing at least one mutation into at least one nucleic acid sequence encoding a nucleotide-binding domain and leucine-rich repeat-containing (NLR) protein, wherein the NLR protein comprises a HD1 domain;
- and wherein the at least one mutation is a mutation of one or more amino acids in an N-terminal portion of the HD1 domain;
- or introducing and expressing a nucleic acid construct comprising a nucleic acid sequence encoding a mutated NLR protein, wherein the NLR protein comprises a HD1 domain, and wherein the NLR protein comprises a mutation of one or more amino acids in an N-terminal portion of the HD1 domain.
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Dependencies are inferred from the claim text.