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US 2026/0201391 A1Published application
Compositions and methods related to multiparatopic aptamers
AssigneeNorth Carolina State University
InventorsYi Xiao, Obtin Alkhamis
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Abstract
The present disclosure provides compositions and methods related to multiparatopic aptamers. In particular, the present disclosure provides nucleic acid aptamers capable of binding multiple distinct epitopes on a target biomolecule, as well as corresponding methods of generating and characterizing the multiparatopic aptamers.
Claims33
A single-stranded nucleic acid molecule comprising:
- an anchor aptamer capable of binding a target biomolecule;
- and
- at least one candidate aptamer coupled to the anchor aptamer, wherein the at least one candidate aptamer comprises a random nucleic acid sequence.
A method of identifying a multiparatopic aptamer, the method comprising:
- exposing a library of candidate multiparatopic aptamers to a target biomolecule, wherein each candidate multiparatopic aptamer in the library comprises an anchor aptamer capable of binding the target biomolecule and at least one candidate aptamer coupled to the anchor aptamer, wherein the at least one candidate aptamer comprises a random nucleic acid sequence;
- and
- assessing binding of the candidate multiparatopic aptamer to the target biomolecule.
Dependencies are inferred from the claim text.