Sirna inhibiting expression of amyloid precursor protein (app) gene, drug, and use

An siRNA or a pharmaceutically acceptable salt thereof for suppressing the expression of the amyloid precursor protein (APP) gene, wherein the siRNA comprises a sense strand and a corresponding antisense strand, and wherein the siRNA is selected from any of the following pairs of sequences, or sequences differing from its sense strand or antisense strand by no more than one nucleotide:

• A) 12006:
• its sense strand is shown in SEQ ID NO:
• 11, and its antisense strand is shown as SEQ ID NO:
• 12;
• B) 12037:
• its sense strand is shown in SEQ ID NO:
• 75, and its antisense strand is shown as SEQ ID NO:
• 76;
• C) 12075:
• its sense strand is shown in SEQ ID NO:
• 151, and its antisense strand is shown as SEQ ID NO:
• 152;
• D) 12076:
• its sense strand is shown in SEQ ID NO:
• 153, and its antisense strand is shown as SEQ ID NO:
• 154.