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US 2026/0201349 A1Published application
TelA Variants, Compositions, and Methods
AssigneeNew England Biolabs, Inc.
InventorsShuang-Yong Xu, Andrew F. Gardner, Daniel Heiter, Pei-Chung Hsieh, Rebecca Kucera, Juan Pan
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Abstract
The present disclosure relates, according to some embodiments, to telomere resolvases (e.g., TelA variants) having a turnover number over 1.
Claims18
A variant protelomerase comprising an amino acid sequence according to SEQ ID NO:
- 1, capable of cleaving and rejoining a polynucleotide comprising a nucleotide sequence according to SEQ ID NO:16 and having a turnover number ≥1.1, wherein the amino acid sequence has at least 95% identity to SEQ ID NO:1 and has at least one of the following properties:
- (a) X1 is T, M-T or M-H8-S-G-T;
- (b) X97 is K or R;
- (c) X98 is A;
- and
- (d) X337 is G or G-H6,
- provided that if X1 is M-H8-S-G-T, X337 is G and if X337 is G-H6, X1 is T or M-T.
4 more elements
Dependencies are inferred from the claim text.