Uricase conjugates and methods of use thereof
OwnerPatrick WIENCEK, Claire GODBERSEN-PALMER +3inventors
InventorsPatrick WIENCEK, Claire GODBERSEN-PALMER, Hongki SONG, Karl GRISWOLD, Nicholas ROSENTHAL
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Abstract
The present invention provides novel uricase conjugates comprising a first domain and a second domain. The first domain comprises a uricase polypeptide and the second domain is an unstructured, random coil polypeptide domain comprising at least about 100 amino acids. Methods for using the uricase conjugates of the invention, for example, in the treatment of tumor lysis syndrome and/or gout, are also provided.
Claims117
A uricase conjugate comprising a first domain and a second domain, wherein the first domain comprises a uricase polypeptide, or an amino acid variant thereof, and the second domain is a first random coil polypeptide domain comprising at least about 100 amino acids.
Dependencies are inferred from the claim text.