Method for differentiating neural crest stem cells comprising axial specification information

Abstract

The present disclosure relates to a method of selectively differentiating and isolating, from pluripotent stem cells, neural crest cells having axial specification information in the body. According to the method of the present disclosure, initial neural crest cells, which correspond to an embryo neurulation stage and have not yet formed axial information in the body, can be produced, neural crest cells having specific axial information in the human body can be produced, and the cells can be specifically isolated and cultured in vitro such that various types of neural crest cells can be obtained all at once, and biological processes of neural crest cells for retaining axial information are researched to identify developmental processes of tissues and organs, and thus various cell therapeutic agents optimized for the characteristics of locations in the human body can be developed.

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