Stem cell-derived embryo model, and construction method therefor and use thereof

A method for screening a drug for intervening in embryonic development during a gastrulation stage, the method comprising:

• adding a candidate drug to a culture process of a method for constructing a stem cell-derived embryo model, the method for constructing a stem cell-derived embryo model comprising culturing naïve stem cells in vitro, or injecting the naïve stem cells into an immunodeficient animal for in vivo differentiation, to obtain the stem cell-derived embryo model;
• or bringing a candidate drug into contact with a stem cell-derived embryo model comprising an extraembryonic tissue and an intraembryonic tissue;
• and
• determining, when the stem cell-derived embryo model obtained by the method for constructing a stem cell-derived embryo model or the stem cell-derived embryo model comprising an extraembryonic tissue and an intraembryonic tissue undergoes an expected change, the candidate drug as a target drug.