Alternative strategies for methanobactin production
AssigneesThe Regents of the University of Michigan, Iowa State University Research Foundation, Inc.
InventorsJeremy D. SEMRAU, Alan DISPIRITO, Peng PENG
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Abstract
The present disclosure relates to systems and methods for the production of methanobactins. In particular, the disclosure provides modified bacteria and methods of use thereof for production of methanobactin.
Claims33
A mutant organism having attenuated expression of a native gene encoding methane monooxygenase component D (MMOD), wherein the mutant organism produces methanobactin when cultured in the presence of methanol.
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A mutant organism having attenuated expression of one or more native genes in a methanobactin gene cluster, wherein the mutant organism expresses one or more heterologous genes in a methanobactin gene cluster from a different species of organism.
Dependencies are inferred from the claim text.