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US 2026/0201291 A1Published application
Integrated system for 3d tissue culture
AssigneeValo Health, Inc.
InventorsRoozbeh Aschar-Sobbi, Maw-Lin Kuo, Roger Stenerson, Winston Sun, Dickshitha Thyagharajon, Ya Kevin Thao, Chris Todd, Brian Wilfley
Life of this patent
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Abstract
Embodiments described herein relate generally to devices, apparatuses, and systems with embedded electrodes for growing, maintaining, and/or using 3D tissues in vitro. The devices, apparatuses, and systems described herein can provide scalable, automated tissue stimulation.
Claims20
A non-transitory processor-readable medium storing code representing instructions to be executed by a processor, the instructions comprising code to cause the processor to:
- receive a set of measurements from at least one sensing element associated with a well configured for growing a tissue from cells seeded within the well, the well including a set of electrodes configured to apply an electrical stimulation to the tissue according to a set of stimulation parameters;
- identify an amount to change a set of values for the set of stimulation parameters based on a comparison of the set of measurements to a set of predetermined criteria associated with the tissue;
- adjust the set of values based on the amount to define an updated set of values for the set of stimulation parameters;
- and
- send a stimulation signal to the set of electrodes to apply the electrical stimulation to the tissue according to the updated set of values for the set of stimulation parameters.
2 more elements
A computer-implemented method comprising:
- receiving a set of measurements from at least one sensing element associated with a well configured for growing a tissue from cells seeded within the well, the well including a set of electrodes configured to apply an electrical stimulation to the tissue according to a set of stimulation parameters;
- identifying an amount to change a set of values for the set of stimulation parameters based on a comparison of the set of measurements to a set of predetermined criteria associated with the tissue;
- adjusting the set of values based on the amount to define an updated set of values for the set of stimulation parameters;
- and
- sending a stimulation signal to the set of electrodes to apply the electrical stimulation to the tissue according to the updated set of values for the set of stimulation parameters.
2 more elements
An apparatus, comprising:
- a memory;
- and
- a processor operatively coupled to the memory, the processor configured to:
- receive a set of measurements from at least one sensing element associated with a well configured for growing a tissue from cells seeded within the well, the well including a set of electrodes configured to apply an electrical stimulation to the tissue according to a set of stimulation parameters,
- identify an amount to change a set of values for the set of stimulation parameters based on a comparison of the set of measurements to a set of predetermined criteria associated with the tissue,
- adjust the set of values based on the amount to define an updated set of values for the set of stimulation parameters, and
- send a stimulation signal to the set of electrodes to apply the electrical stimulation to the tissue according to the updated set of values for the set of stimulation parameters.
4 more elements
Dependencies are inferred from the claim text.