Back to results
US 2026/0201166 A1Published application
Polyesteramide copolymers possessing high glass transition temperatures
AssigneeDsm IP Assets B.V.
InventorGueorgui Mihov
Life of this patent
Estimating the term…
Abstract
Disclosed herein are polyesteramide random copolymers having high glass transition temperatures, methods of forming such polymers, devices, formulations, and medical devices containing such polymers, and methods of treating mammals suffering from various conditions using such polymers in combination with a bioactive agent. In an embodiment, the random copolymers may have a Tg above body temperature, about 37° C., and may achieve a longer release duration, different release kinetics, improved barrier properties, or other benefits over polymers with Tg below 37° C.
Claims20
A random copolymer according to Formula I:
- wherein
- m is from 0 to 0.20, n is from 0.80 to 0.95, q is from 0 to 0.15, and m+n+q=1, wherein m, n, and q represent the equivalents of the corresponding units in the random copolymer;
- p is about 5 to about 300;
- R1 is C2-C20 alkylene;
- R4 is hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10) aryl, —CH2SH, —(CH2)2S(CH3), —CH2OH, —CH(OH) CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+) NH2, —CH2COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, (CH3)2CH—, Ph-NH—,
- R6 is according to Formula II;
- R7 is (C6-C10) aryl(C1-C6)alkylene;
- and
- R8 is C3-C8 alkylene, and
- wherein the random copolymer has a wet Tg of 37° C. or greater, wherein the wet Tg is the initial wet Tg after soaking in PBS buffer solution for 4 days.
7 more elements
Dependencies are inferred from the claim text.