Functionalized and non-functionalized amphiphilic polymers based on polyacrylic acid for the solubilization, isolation and molecular labelling of membrane proteins in aqueous media

A water-soluble membrane protein solubilizing polymer having the general formula (1)

• wherein
• X is either the initiator fragment derived by the radical starter molecule used for preparing the polymer or a functional group or a hydrogen atom;
• Y is a functional group, a hydrogen atom or a terminal RAFT agent usable for further functionalization and can also be conjugated with other molecules like fluorophore, and biomolecular tag;
• a as well as b denotes for the relative number of statistically distributed units of the polymer and give rise to the molecular weight of the polymer;
• R1 is a hydrophilic part of the polymer based on grafted proteinogenic and non-proteinogenic amino acids and amino acid derivatives, and polar functional groups like Phosphoethanolamin and derivates;
• R2 is a hydrophobic part of the polymer based on grafted proteinogenic and non-proteinogenic amino acids and amino acid derivatives.