Novel crosslinked alginic acid
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsShoji FURUSAKO, Tomohiro NARUMI, Tsutomu SATOH
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Abstract
The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.
Claims18
An alginic acid derivative of formula (I) below, consisting of a cyclic alkyne group (Akn) introduced via an amide bond and a divalent linker (-L1-) at any one or more carboxyl groups of alginic acid:
- in formula (I), (ALG) is alginic acid;
- —NHCO— is an amide bond via any carboxyl group of alginic acid;
- -L1- is a divalent linker selected from the group consisting of the following partial structural formula excluding the parts outside the cutting lines at both ends of each formula:
- and Akn is a cyclic alkyne group selected from the group consisting of the following partial structural formulae, excluding the part to the right of the cutting line in each formula:
- in which the asterisks represent chiral centers.
An alginic acid derivative selected from the group consisting of the following formula:
- wherein in each formula, (ALG) is alginic acid;
- and —NHCO— bound to (ALG) is an amide bond via any carboxyl group of alginic acid.
A method for producing an alginic acid derivative represented by formula (I) or a salt thereof, the method comprising:
- causing a condensation reaction of an alginic acid or a salt thereof with an amine derivative of Formula (AM-1) or a salt thereof by using a condensing agent to obtain the alginic acid derivative of formula (I) or a salt thereof,
- Formula (I):
- in formula (I), (ALG) is alginic acid;
- —NHCO— is an amide bond via any carboxyl group of alginic acid;
- -L1- is a divalent linker selected from the group consisting of the following partial structural formula and Akn is a cyclic alkyne group selected from the group consisting of the following partial structural formulae, excluding the part to the right of the cutting line in each formula, excluding the parts outside the cutting lines at both ends of each formula:
- -L1-:
- Akn:
- in formula (AM-1), -L1- is defined as in formula (I).
Dependencies are inferred from the claim text.