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US 2026/0201069 A1Published application
Antibodies that specifically bind modified oligonucleotides
AssigneeHoffmann-La Roche Inc.
InventorsJoerg BENZ, Ulrich BRINKMANN, Thomas EMRICH, Guy GEORGES, Hung-En HSIA
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Abstract
Herein is reported an anti-LNA antibody comprising six HVRs of SEQ ID NO: 42, 44, 46, 51, 53 and 55.
Claims13
An anti-LNA antibody comprising
- (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 42;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 44;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 46;
- (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 51;
- (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 53;
- and
- (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 55.
10 more elements
A multispecific antibody comprising
- at least one first binding site specifically binding to LNA and comprising
- (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 42;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 44;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 46;
- (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 51;
- (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 53;
- and
- (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 55;
- at least one second binding site specifically binding to a second non-LNA target,
- an Fc-region comprising a first Fc-region polypeptide and a second Fc-region polypeptide,
- wherein the at least one binding site specifically binding to LNA is conjugated to the C-terminus of one of the Fc-region polypeptides and the at least one binding site specifically binding to a second non-LNA target is conjugated to the N-terminus of one of the Fc-region polypeptides.
14 more elements
Dependencies are inferred from the claim text.