Compositions, methods and/or kits comprising a recombinant human cd38-extracellular domain
AssigneeGrifols Diagnostic Solutions Inc.
InventorsVincenzo FAVALORO, Matteo BINDA, John A. Hall, Elizabeth Booth, Jody BERRY, Peter SCHWIND
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Abstract
A composition that binds to an anti-CD38 antibody includes a specific sequence of a recombinant soluble form of an extracellular domain of CD38 and/or a fragment thereof that interferes with binding activity of the anti-CD38 antibody. The composition can be included in a kit for bio-monitoring research and diagnostic assays. The composition can be used to neutralize an anti-CD38 antibody in a sample and/or to select a suitable red blood cell unit for a patient treated with anti-CD38 antibodies.
Claims23
A composition for binding to an anti-CD38 antibody, the composition comprising a recombinant protein comprising a soluble form of an extracellular domain of CD38 or a fragment thereof fused to immunoglobulin Fc region or a fragment thereof, wherein the recombinant protein interferes with a binding activity of an anti-CD38 antibody.
A recombinant protein comprising an extracellular domain of CD38 or a fragment thereof fused to immunoglobulin Fc region, or a fragment thereof, wherein the recombinant protein interferes with a binding activity of an anti-CD38 antibody.
Dependencies are inferred from the claim text.