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US 2026/0201012 A1Published application
Engineered immune cells with receptor signal strength modulated by a hinge
AssigneeA2 Biotherapeutics, Inc.
InventorAlexander Kamb
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Abstract
The present disclosure provides engineered immune cells and methods for their creation and use. The immune cells comprise activating and blocking receptors, that exhibit cross-talk between the receptors.
Claims20
A method of producing an engineered immune cell, the method comprising:
- determining a strength of a blocking signal sent from a cell surface blocking receptor on an engineered immune cell at least in-part due to a length of a hinge of the cell surface blocking receptor, wherein different hinge lengths impart different signal strengths for the cell surface blocking receptor;
- and
- producing an engineered immune cell that comprises a cell surface activating receptor that sends an activating signal that is inhibited by the blocking signal and the cell surface blocking receptor with a determined hinge length.
Dependencies are inferred from the claim text.