Recombinant var2csa protein, and preparation method and use thereof
AssigneeSun Yat-sen University Cancer Center (The Affiliated Cancer Hospital of Sun Yat-sen University, The
InventorsWeihua Jia, Peifen Zhang, Ziyi Wu, Wenbin Zhang, Yongqiao He, Quankai Mu
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Abstract
Provided is a recombinant VAR2CSA protein, and a preparation method and use thereof. The provided recombinant VAR2CSA protein and the preparation method thereof feature high stability and high yield, as well as good efficiency and capacity in detecting oncofetal chondroitin sulfate (ofCS) and an oncofetal chondroitin sulfate proteoglycan (ofCSPG), can be used for large-scale production of proteins for detection of ofCS/ofCSPG, and are used for early screening, diagnosis, tumor burden monitoring, and prognosis prediction of malignant tumors.
Claims21
1-15. (canceled)
A recombinant VAR2CSA protein, wherein the recombinant VAR2CSA protein comprises an amino acid sequence having at least 70%, at least 75%, at least 80%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% identity to any one of SEQ ID NOS:1-4.
Dependencies are inferred from the claim text.