Expression of antigen-adjuvant fusion subunit proteins in diatoms, and methods of generation and use thereof
AssigneePhycoVax LLC
InventorsRoshan SHRESTHA, Thomas GRIMM
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Abstract
This application relates to compositions and methods used to treat animals with at least one microbial protein, such as a flagellin protein. In embodiments, application relates to compositions and methods to treat animals with a fusion protein comprising at least one adjuvant protein, such as a flagellin protein. In embodiments, the composition further includes at least one adjuvantic protein fused with at least one antigen protein, and the fusion protein is expressed in diatoms.
Claims22
A composition, comprising a sequence having at least 80% sequence identity with any of SEQ ID NOs:
- 3, 12, 13, 14, 15, 16, 17, 18, and 19.
5-9. (canceled)
A method of treating an animal, comprising administering a therapeutically effective amount of at least one protein derived from a microbe to the animal.
(canceled)
The method of claim 33, wherein the at least one diatom comprises any one or more of Thalassiosira pseudonana, Thalassiosira weissflogii, Cyclotella cryptica, or Chaetoceros muelleri.
21-32. (canceled)
A method of treating an animal, comprising:
- adding at least one protein from a microbe to a diatom cell;
- and
- administering the diatom cell to the animal.
37-56. (canceled)
Dependencies are inferred from the claim text.