Engineered virus-like-particles for targeted capture of membrane proteins
OwnerMart Ustav, JR., Sachdev Sidhuinventors
Life of this patent
Estimating the term…
Abstract
Disclosed are engineered virus-like-particles (VLPs) and their use. In the VPLs integral plasma membrane proteins are captured and displayed on the surface of a VLP in a native conformation based on an interaction between a viral scaffolding protein fused to a PDZ domain and a synthetic polypeptide in the cytoplasmatic C-terminal tail of the target membrane protein.
Claims18
A virus-like-particle (VLP) expressing one or more membrane embedded proteins on its surface and comprising a viral scaffolding protein fused to a PDZ domain and a synthetic polypeptide in cytoplasmic C-terminal tail of the one or more target membrane proteins, and optionally a signal peptide incorporated at the N-terminal end of the one or more target membrane proteins.
Dependencies are inferred from the claim text.