Modified long peptides suitable for use in immunisation
AssigneeIsabella Pharma B.V.
InventorsBrigitte Elisa Anna BURM, Thomas Johannes Maria BEENAKKER, Lucien Nathanaël LAMEIJER, Esmé Teunisje Ida VAN DER GRACHT
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Abstract
The present invention relates to the field of immunology. In particular, it relates to novel long cysteine-containing immunogenic peptides, wherein the cysteine has been modified to yield a more stable product while preserving immunogenicity. The invention further relates to compositions and methods for treating diseases using the long immunogenic peptides of the invention.
Claims16
An immunogenic peptide of 20 to 45 amino acid residues in length comprising one or more cysteine residues, wherein said one or more cysteine residues is present in a modified form wherein said one or more cysteine residue is bound to a cysteine or other thiol-containing compound via a disulfide bond, wherein said disulfide bond is not an intramolecular disulfide bond between two cysteine residues within the same immunogenic peptide molecule and wherein said disulfide bond is also not an intermolecular disulfide bond connecting two immunogenic peptide molecules.
Dependencies are inferred from the claim text.