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AssigneeHoffmann-La Roche Inc.
InventorsAtaurehman ALI, Simon Thomas AUSLAENDER, Ulrich BRINKMANN, Steffen DICKOPF, Julia FAKHIRI, Linda Elise FRANKEN, Guy GEORGES, Hubert KETTENBERGER, Nico LAUMANN-LIPP, Jens NIEWOEHNER, Johannes REUSCH, Tilman Sebastian SCHLOTHAUER, Tobias STRITTMATTER
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Herein is reported a novel variant adeno-associated virus (AAV) capsid protein comprising a heterologous peptide or polypeptide covalently inserted in the GH-loop of the capsid protein relative to a corresponding parental AAV capsid protein, wherein the heterologous peptide or polypeptide comprises a recognition sequence of a transglutaminase and the amino acids residues at positions 452-455 or 453-459 of VP1 of AAV-2 (SEQ ID NO: 65) or at the corresponding positions in the capsid protein of another AAV serotype are replaced by the heterologous peptide or polypeptide or inserted at amino acid position 456.
A variant adeno-associated virus (AAV) capsid protein comprising a heterologous peptide or polypeptide covalently inserted into or replacing a part of the GH-loop of the capsid protein relative to a corresponding parental AAV capsid protein, wherein the heterologous peptide or polypeptide comprises a recognition sequence of a transglutaminase.
A variant adeno-associated virus (AAV) capsid protein comprising a heterologous peptide or polypeptide covalently inserted into or replacing a part of loop 4 or loop 8 of the capsid protein relative to a corresponding parental AAV capsid protein, wherein the heterologous peptide or polypeptide comprises a recognition sequence of a transglutaminase.
A variant adeno-associated virus (AAV) capsid protein comprising a heterologous peptide or polypeptide covalently inserted relative to a corresponding parental AAV capsid protein, wherein
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A variant adeno-associated virus (AAV) capsid protein comprising the amino acid sequence of SEQ ID NO:
A variant adeno-associated virus (AAV) capsid protein comprising the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.