Ligands specific for asct1
AssigneesMetafora Biosystems, Centre National De La Recherche Scientifique, Universite De Montpellier, The United States of America, as represented by the Secretary, Department of Health and Human
InventorsJacinthe MEKARY, Jawida TOUHAMI, Philippe YOUKHARIBACHE, Donatella GIOVANNINI, Marc SITBON
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Abstract
Polypeptides capable of specifically recognizing and binding to the neutral amino acid transporter ASCT1/SLC1A4, while not binding to the related neutral amino acid transporter ASCT2/SLC1A5. Also, both in vitro and in vivo methods of specifically detecting or/and measuring the level of ASCT1, and to the use of said polypeptides in diagnosis and therapy.
Claims17
1-15. (canceled)
A polypeptide of sequence SEQ ID NO:
- 1 or a functional variant thereof, which specifically binds to ASCT1 and does not specifically bind to ASCT2, wherein:
- SEQ ID NO:
- 1 consists of (X)n-SEQ ID NO:
- 2-(Y)m (Formula (A));
- (X)n is a sequence of n amino acids;
- (Y)m is a sequence of m amino acids;
- “—” designates a peptide bound;
- n≥0 and m≥0;
- and
- if m≥1 then (Y)m does not comprise or consist of the m first amino acids of the sequence SEQ ID NO:
- 3 or a functional variant thereof, said functional variant of the m first amino acids of the sequence SEQ ID NO:
- 3 being such that SEQ ID NO:
- 2-(Y)m specifically binds to ASCT2;
- and
- wherein the functional variant of SEQ ID NO:
- 1 has a sequence comprising a functional variant of SEQ ID NO:
- 2 instead of SEQ ID NO:
- 2, wherein said functional variant of SEQ ID NO:
- 2 specifically binds to ASCT1.
Dependencies are inferred from the claim text.