Her receptor derived peptides and methods of use thereof
AssigneeRamot at Tel-Aviv University Ltd.
InventorRonit PINKAS-KRAMARSKI
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Abstract
HER receptor derived peptides are provided. Accordingly there is provided a composition of matter comprising a peptide comprising an amino acid sequence of a nuclear localization sequence (NLS) of a HER receptor capable of binding a nucleolin polypeptide, the peptide being attached to a cell penetrating moiety. Also provided are polynucleotides encoding the composition of matter, host cells expressing the composition of matter and methods of using same.
Claims34
A composition of matter comprising a peptide comprising an amino acid sequence of a nuclear localization sequence (NLS) of a HER receptor capable of binding a nucleolin polypeptide, said peptide being attached to a cell penetrating moiety.
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A polynucleotide encoding a peptide comprising an amino acid sequence of a nuclear localization sequence (NLS) of a HER receptor capable of binding a nucleolin polypeptide, said amino acid sequence of said NLS does not exceed 16 amino acids.
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A method of producing a peptide, the method comprising chemically synthesizing a peptide comprising an amino acid sequence of a nuclear localization sequence (NLS) of a HER receptor capable of binding a nucleolin polypeptide, said amino acid sequence of said NLS is 16 amino acids long or less.
Dependencies are inferred from the claim text.