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US 2026/0200943 A1Published application
Compounds for treating cancer
AssigneeGenesis Therapeutics, Inc.
InventorsSung Wook Yi, Brandon Reinus, Advait Nagle, Evan Nathaniel Feinberg
Life of this patent
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Abstract
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof, as well as processes for preparing compounds of Formula (I), and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer.
Claims147
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring A is a C3-C10 cycloalkyl optionally substituted with 1-3 independently selected R1;
- each R1 is independently selected from halogen and C1-C6 alkyl;
- Ring B is 5-10 membered heteroaryl optionally substituted with 1-3 independently selected R2;
- each R2 is independently selected from halogen, cyano, C1-C6 alkyl, and C1-C6 haloalkyl;
- Ring C is C4-C6 cycloalkyl, 4-6 membered heterocyclyl, phenyl, or 5-6 membered heteroaryl, wherein Ring C is optionally substituted with 1-3 independently selected R3;
- each R3 is independently selected from halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, —NRARB, —SO2RA, —NHSO2RA, and —SO2NRARB,
- each RA and RB is independently selected from hydrogen, C1-C6 alkyl, and C1-C6 haloalkyl;
- or
- RA and RB together with the nitrogen atom to which they are attached form a 4-8 membered heterocyclyl optionally substituted with 1-2 substituents independently selected from halogen and C1-C6 alkyl;
- L1 is a bond;
- L2 is —NH— or —N(CH3)—;
- L3 is a bond, —NH—, —N(CH3)—, —O—, *—SO2NH—, *—NHSO2—, *—C(═O) NH—, or *—NHC(═O)—, wherein * denotes the point of connection to Ring C;
- X is a C2-C15 alkylene, a C4-C15 alkenylene, or a C5-C15 alkynylene, wherein X is optionally substituted with 1-6 independently selected RY and wherein 1-4 methylene units of X are optionally and independently replaced by —O—, —NH—, —N(C1-C6 alkyl)-, —(C3-C6 cycloalkyl)-, or -(5-6 membered heteroaryl)-;
- each Rx is independently selected from halogen and C1-C6 alkyl;
- L4 is a bond, *—(CH2)m—O—C(═O) NH—, or *—(CH2)m—NHC(═O) NH—, wherein * indicates the point of attachment to Ring A;
- and
- m is 0, 1, or 2.
15 more elements
Dependencies are inferred from the claim text.