Molecular glue degrader compounds and uses thereof
AssigneesNovartis AG, The Regents of the University of California
InventorsJeffrey M. McKenna, Daniel K. Nomura, Ethan Shigeru Toriki, James William Papatzimas, Dustin Leard Dovala, Matthew James Hesse, Kaila Yukika Nishikawa
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Abstract
Described herein are molecular glue degrader compounds that bind to both a target protein and a RING E3 Ubiquitin Ligase, as well as related compositions and methods of use, e.g., for degradation of the target protein and/or the treatment of a disease, disorder, or condition.
Claims40
A molecular glue degrader compound of Formula (I):
- or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein:
- (i) the Target Ligand is capable of binding to a target protein;
- (ii) Bridge is absent or a linker;
- and
- (iii) the RING E3 Ligase Binder is capable of binding to a RING E3 ubiquitin ligase (e.g., RNF126 or BCA2).
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Dependencies are inferred from the claim text.