Preparation method for nitrogen-containing fused ring compound
AssigneeSichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
InventorsYong Liang, Wanlong Tang, Dongliang Xia, Kai Chen, Hongxia Qi, Yufeng Liang, Hongmei Song, Junyou Ge
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Abstract
The present application provides a preparation method for a nitrogen-containing fused ring compound having anti-tumor activity. According to the method, a target product can be efficiently obtained under relatively mild reaction conditions, and upon comparison with the original processes, the yield rate is remarkably improved, and the material cost is greatly reduced, thereby better facilitating process scale-up.
Claims22
A method for preparing a compound as shown in Formula (III), comprising a step of reacting a compound as shown in Formula (II) and Compound 2 in the presence of a catalyst;
- wherein, R1 and R2 are independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C1-6 alkoxy, C1-4 haloalkyl, hydroxyl and cyano;
- or R1 and R2, together with the carbon atoms to which they are connected, form a 5- to 6-membered carbon ring or an oxygen-containing heterocyclic ring;
- R3 is an electron-withdrawing protective group;
- the catalyst is selected from one or more of PPTS, AcOH, TFA, H2SO4, proline, PPA, P2O5, CAN, T3P, KOH, I2, MgCl2 and TMSCl.
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Dependencies are inferred from the claim text.