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AssigneeWisconsin Alumni Research Foundation
InventorsTimothy Bugni, Fan Zhang, Douglas R. Braun, David Andes, Miao Zhao
Estimating the term…
Turbinmicin, an isolated compound of Formula I or IA is provided. Turbinomycin compounds of Formula II or IIA are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount for treating a fungal infection of a compound of Formula I:
The pharmaceutical composition of claim 11, wherein the second antifungal agent or combination of antifungal agents is selected from the group consisting of azoles, echinocandins, and polyenes.
The pharmaceutical composition of claim 11, wherein the second antifungal agent or combination of agents is selected from the group consisting of amphotericin B, flucytosine, fluconazole, voriconazole, posaconazole, isavuconazole, micafungin, cyphomycin, and forazoline.
Dependencies are inferred from the claim text.