Pyridine polycyclic compound inhibitor, preparation method therefor and use thereof

A compound represented by general formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof:

• wherein:
• is a single bond or a double bond;
• ring A is 5- to 7-membered heterocyclyl containing 2-3 heteroatoms selected from N, O, or S, and ring A contains at least one oxygen atom;
• ring B is 5- to 6-membered heteroaryl or phenyl;
• ring C is cycloalkyl, heteroaryl, heterocyclyl, or absent;
• M1, M2, M4, M5, and M6 are each independently selected from N, C, NH, or CH;
• M3 is a bond, N, or CH;
• each R1 is independently selected from cycloalkyl, heterocyclyl, cycloalkyloxy, heterocyclyloxy, cycloalkylamino, heterocyclylamino, cycloalkylthio, heterocyclylthio, —C(O)(CH2)nRb, —NRaC(O)(CH2)nRb, —O(CH2)nRb, —NH(CH2)nRb, —S(CH2)nRb, —S(O)2(CH2)nRb, —S(O)(NH)(CH2)nRb, —NRaS(O)2(CH2)nRb, —NRaS(O)(NH)(CH2)nRb, or —NS(O)(CH2)nRaRb, wherein optionally the cycloalkyl, heterocyclyl, cycloalkyloxy, heterocyclyloxy, cycloalkylamino, heterocyclylamino, cycloalkylthio, or heterocyclylthio is further substituted with one or more substituents selected from oxo, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, —C(O)(CH2)nRb, —S(O)2(CH2)nRb, —S(O)(NH)(CH2)nRb, —S(O)2(CH2)nRb, or —NRaS(O)(NH)(CH2)nRb;
• or any two R1, together with adjacent carbon atoms, form 3- to 8-membered cycloalkyl or 4- to 7-membered heterocyclyl, wherein optionally the 3- to 8-membered cycloalkyl or 4- to 7-membered heterocyclyl is further substituted with oxo, —C(O)Rb, —NRaC(O)Rb, —S(O)2Rb, —S(O)(NH)Rb, —NRaS(O)2Rb, or —NRaS(O)(NH)Rb;
• Ra or Rb is each independently selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein optionally the cycloalkyl, aryl, heteroaryl, or heterocyclyl is further substituted with one or more substituents selected from oxo, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, or —S(O)2alkyl;
• R2, R3, or R4 is each independently selected from hydrogen, deuterium, oxo, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein the alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NRaC(O)(CH2)nRb, or —C(O)NRa(CH2)nRb can be optionally further substituted;
• or R2 and R3, together with adjacent atoms, form 3- to 8-membered cycloalkyl, 5- to 6-membered heteroaryl, or 4- to 7-membered heterocyclyl, wherein optionally the 3- to 8-membered cycloalkyl, 5- to 6-membered heteroaryl, or 4- to 7-membered heterocyclyl is further substituted with one or more substituents selected from oxo, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, or hydroxyalkyl;
• or any two R2, together with adjacent atoms, form 3- to 8-membered cycloalkyl, 5- to 6-membered heteroaryl, or 4- to 7-membered heterocyclyl, wherein optionally the 3- to 8-membered cycloalkyl, 5- to 6-membered heteroaryl, or 4- to 7-membered heterocyclyl is further substituted with one or more substituents selected from oxo, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, or hydroxyalkyl;
• or R2 and R4, together with adjacent atoms, form 5- to 14-membered cycloalkyl, 5- to 14-membered heteroaryl, or 5-14-membered heterocyclyl, wherein optionally the 5- to 14-membered cycloalkyl, 5- to 14-membered heteroaryl, or 5-14-membered heterocyclyl is further substituted with one or more substituents selected from oxo, deuterium, halogen, amino, hydroxyl, cyano, nitro, alkyl, alkenyl, alkynyl, deuteroalkyl, haloalkyl, alkoxy, haloalkoxy, or hydroxyalkyl;
• p, x, y, and z are each independently selected from 1, 2, 3, or 4;
• and
• n is selected from 0, 1, 2, or 3.