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US 2026/0200904 A1Published application
Fused tricyclic derivative and pharmaceutical application thereof
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsPeng ZHANG, Yunfu LUO, Feng GAO, Shuhui CHEN
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Abstract
Disclosed are a fused tricyclic derivative and a pharmaceutical application thereof. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.
Claims20
1-19. (canceled)
A compound of formula (III) or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is selected from the group consisting of H, —Cl, —Br, methyl, tert-butyl and phenyl;
- R2 is each independently selected from the group consisting of H, —Cl, —Br, methyl and tert-butyl;
- or two R2, together with the thiophene ring to which they are connected, form benzothiophene;
- n is selected from the group consisting of 1 and 2;
- T1 is selected from the group consisting of a single bond and —N(CH3)—;
- L1 is selected from the group consisting of a single bond and —CH2—;
- the structural unit
- is selected from the group consisting of
- ring A is selected from the group consisting of the following groups optionally substituted with 1 or 2 Rb:
- pyrazolyl and phenyl;
- Rb is each independently selected from the group consisting of —F, —Cl, —Br, —I, —CH3 and —CH2CH3;
- ring B is selected from the group consisting of cyclohexyl and the following groups optionally substituted with 1 Ra:
- piperidinyl, piperazinyl,
- Ra is selected from the group consisting of —F, —Cl, methyl, —OH and —CN.
12 more elements
A compound, which is selected from the group consisting of
Dependencies are inferred from the claim text.