US 2026/0200900 A1 · PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS

Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

AssigneeVertex Pharmaceuticals Incorporated

InventorsCristian HARRISON, Paloma BENITO GALLO, Shujauddin M. CHANGI, Christopher John DAVIS, Simon Robert EVERITT, Enrico EMER, Kevin J. GAGNON, Bérénice L. LEWANDOWSKI, Andrew McTIERNAN, Ales MEDEK, Michael Edward O'DONNELL, Simon Adam O'NEIL, Maninder PANESAR, Mireia SIDERA PORTELA, Stephen Edward SHANAHAN, Bruno Artur SOUSA, David E. STEPHENS, Tharanga K. WIJETHUNGA

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Abstract

Provided in this application is a process for making a compound of formula (I) and pharmaceutically acceptable salts thereof, which are useful as inhibitors of sodium channels. Also provided in this application is a process for making a compound of formula (II) and pharmaceutically acceptable salts thereof, which are useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.

Claims45

Dependent claims

A process for preparing a compound of formula (I):

comprising transforming a compound of formula (IV):
or a salt thereof, to the compound of formula (I).

Dependencies are inferred from the claim text.