Inhibitors of spns2 and uses thereof

A compound having a structure according to Formula (I):

• wherein:
• X is —C(H)═ or —N═;
• Y is —C(H)═ or —N═, wherein at least one of X and Y is not —C(H)═;
• R1 is a hydrogen, —Cl, —F, or a C1-C6 alkyl;
• R2 is a hydrogen, —Cl, —F, or a C1-C6 alkyl;
• R3 is —Cl, R5, —OR5, —NHR5, or —N(R5)2;
• R4 is —OR5, —NHR5, —N(R5)2,
• R5 is independently at each occurrence an optionally substituted C1-C12 alkyl, an optionally substituted C1-C12 alkenyl, an optionally substituted C1-C12 alkoxy, an optionally substituted ring selected from phenyl, a 3-7 membered saturated or partially unsaturated carbocyclyl, a 4-7 membered saturated or partially unsaturated heterocyclyl having 1-2 heteroatoms independently selected from N, O, and S, a 5-6 membered heteroaryl having 1-4 heteroatoms independently selected from N, O, and S, a fused bicyclic ring system having 1-4 heteroatoms independently selected from N, O, and S, or an optionally substituted combination of any two of a C1-C12 alkyl, a C1-C12 alkenyl and a ring;
• Z is —C(H)—, —CH2—, or —O—;
• R6 is independently at each occurrence an optionally substituted C1-C12 alkyl;
• an optionally substituted C1-C12 alkenyl;
• an optionally substituted phenyl, —N(R*)2, —OR*, —N(R*)C(O)R*, —NH—SO2—R*, —C(O)N(R*)2, or
• R* is independently at each occurrence hydrogen, an optionally substituted C1-C12 alkyl, an optionally substituted C1-C12 polyfluoroalkyl;
• an optionally substituted phenyl, an optionally substituted 3-7 membered saturated or partially unsaturated carbocyclyl;
• a 4-7 membered saturated or partially unsaturated heterocyclyl having 1-2 heteroatoms independently selected from N, O, and S,
• or a pharmaceutically acceptable salt thereof,
• with a proviso that wherein (i) R1 and R2 are both hydrogens, X and Y are both —N═, and R3 is a 6 membered saturated heterocyclyl having 2 nitrogen atoms, R4 is not
• (ii) R1 and R2 are both hydrogens, X and Y are both —N═, and R3 is phenyl substituted with —OCH3 or —F,
• R4 is not
• or
• (iii) R1 is a hydrogen, —Cl, —F, or a C1-C6 alkyl;
• R2 is a hydrogen, —Cl, —F, or a C1-C6 alkyl;
• X is —N═;
• Y is —C(H)═ or —N═;
• and R3 is —CH3 or a combination of C1-C4 alkylene and a fused bicyclic ring system consisting of two fused six-membered aromatic rings containing at least one nitrogen atom, R4 is not