Cannabinoid receptor 2 modulators

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from hydroxy, amino, and a group
• X is selected from a covalent bond, —O—, —NRx—, —NRxC(O)—(CH2)q—, —C(O)NRx—, —C(O)—(CH2)q—, —C(O)—(CH2)q—NRxC(O)—, —C(O)—CH2—(CH2)q—C(O)O—, —C(O)—CH2—O—, and —C(O)—CH2—S—;
• Rx is selected from hydrogen and methyl;
• p is an integer selected from 1, 2, 3, 4, 5, and 6;
• q is an integer selected from 0, 1, 2, 3, 4, and 5;
• R2 and R3 are each independently selected from C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C6-C10-aryl, and 5- to 14-membered heteroaryl;
• wherein said C6-C10-aryl and 5- to 14-membered heteroaryl are optionally substituted with 1-3 substituents independently selected from halogen, cyano, hydroxy, amino, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, and halo-C1-C6-alkoxy;
• R4 is selected from:
• R4a and R4b are each independently selected from hydroxy, amino, dimethylamino, and azetidinyl;
• R4c and R4d are each independently selected from hydrogen and —SO3H;
• R4e, R4f, and R4g are each independently selected from hydrogen and halogen;
• Y is selected from Se, S, O, C(CH3)2, C(CD3)2, NCH2C≡CH and
• Z is selected from O, S and Si(CH3).