Adar1 inhibitors and methods of using the same

A compound of Formula (I) having the structure:

• or a pharmaceutically acceptable salt or tautomer thereof,
• wherein:
• L is a linker having structure -A-L1-B—,
• wherein:
• A is, —NRc—, —NRcC(O)—, —C(O)NRc—, —NRcS(O)2—, or —S(O)2NRc—;
• L1 is absent, alkylene, alkenylene, alkynylene, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• B is a bond, —NRd—, —N(S(O)2-alkyl)-, —NRdC(O)—, —OC(O)—,
• —OC(CF3)—, —O—, —C(O)-alkylene-, —C(O)—, —NRdS(O2)—, —S(O2) NRd—, or heteroaryl;
• Rc and Rd are each independently H, alkyl, cycloalkyl, heterocyclyl, alkylene-aryl, acyl, or sulfonyl,
• with the proviso that -A-L1-B— does not contain an —O—O, —NRc—O, —O—NRd—, —NRc—NRd—, or S—S bond;
• X is C—R1 or N;
• Y is C—R4 or N;
• Z is O, S, N—R5, or N(R5)—CH2—;
• Z3, Z4, Z5, Z6, and Z7 are each independently N or CH, wherein no more than 2 of Z3, Z4, Z5, Z6, and Z7 are N;
• R1 is H, halogen, alkyl, —CN, —C(O)Ra, —C(O)ORa, —C(O)NHRa, —C(O)N(alkyl)(Ra), —C(O)N(Ra)(Ra), —C(O)NRaRa, or —S(O)2Ra, or —S(O)2ORa, or R1 and Rc taken together with the atoms to which they are attached form a heterocyclyl or heteroaryl;
• R2 is H, halogen, alkyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocyclyl, or heterocycloalkenyl;
• R3 is each independently halogen, —OH, —CH2OH, alkyl, haloalkyl, alkoxy, haloalkoxy, —S(O)2NHRb, —S(O)2NRbRb, —NHS(O)2Rb, —C(O)Rb, —C(O)ORb, —C(O)NHRb, —C(O)NRbRb, —NHC(O)Rb, —NHC(O)NRbRb, —CN, or —P(O)(ORb)2, or two R3 taken together with the adjacent carbon atoms to which they are attached form an aryl, cycloalkyl, or heterocyclyl;
• R4 is H, halogen, alkyl, —C(O)ORa, —C(O)NHRa, or aryl, or R2 and R4 taken together with the carbon atoms to which they are attached form a cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• R5 is H, alkyl, alkylenecycloalkyl, cycloalkyl, aryl, alkylenearyl, or heteroaryl, or R2 and R5 taken together with the adjacent carbon atoms to which they are attached form an aryl or heteroaryl;
• Ra is each independently H, alkyl, cycloalkyl, alkylene-cycloalkyl, aryl, heteroaryl, alkylene-aryl, or alkylene-heteroaryl, or two Ra groups taken together with the nitrogen atom to which they are attached form a heterocyclyl;
• Rb is H, alkyl, cycloalkyl, alkylene-cycloalkyl, heterocyclyl, or aryl, or two Rb groups taken together with the nitrogen atom to which they are attached form a heterocyclyl;
• and
• m is 0, 1, 2, or 3,
• wherein the compound is not: