Benzopyrone compounds as well as preparation method therefor and use thereof

A benzopyrone-based compound represented by formula (I), or stereoisomer thereof, or salt thereof, or prodrug thereof, or deuteride thereof, or hydrate thereof, or solvate thereof,

• wherein X1 and X2 are each independently selected from the group consisting of O or NH group;
• Y is selected from the group consisting of CR group or N, wherein R is H or C1-C3 alkyl;
• R1 and R1′ may be identical or different and are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl;
• L1 and L3 are each independently selected from the group consisting of —O—, —S—, —NR3—, —CR2R3—, —CR2(R3), —CO—, —SO— or —SO2— groups, L2 is a direct linkage, —CR2R3—, —CR2(R3)— or —C(R2R3)—;
• or, the -L1-L2-L3- as a whole is any one selected from the group consisting of —O—CH(CH3)—CO—, —O—CR2(R3)—CO—, —O—CR2R3—CO—, —CR2R3—CH(CH3)—CO—, —CR2(R3)—CR2(R3)—CO—, —NR3—CH(CH3)—CO—, —NR3—CR2(R3)—CO—, —S—CH(CH3)—CO—, —S—CR2(R3)—CO—, —SO2—CH(CH3)—CO—, —SO2—CR2(R3)—CO—, —O—CR2(R3)—CR2(R3)—, —O—CR2(R3)—CR2(R3)—, —O—CH(CH3)—SO2—, —O—CR2(R3)—SO2— and —CRZ(R3)—NR3—CO—;
• wherein R2 is selected from the group consisting of H or C1-C4 linear alkyl;
• R3 is selected from the group consisting of H or C1-C4 linear alkyl;
• or R2 and R3 in a group of —CR2(R3) together form an oxo group;
• R4, R5 and R6 are each independently selected from the group consisting of H, halogen, —C—OR8(R9), —CR8(R9), —CN, —NO2, —OR8, —NR8R9, —SR8, —COR8, —SOR8, —SO2R8, —NR8COR9, —CONR8R9, —OCOR8, —COOR8, —OCONR8R9, —NR8CONR9R10, —NR8COOR9, —NR8SO2R9, —SO2NR8R9, —OSO2R8, —SO3R8, linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl, or aromatic fused heterocyclyl, wherein R8, R9 and R10 are each independently selected from the group consisting of H, linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
• wherein the linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be independently substituted with one or more R11 selected from the group consisting of halogen, cyano, hydroxyl, mercapto, ether group, nitro, alkoxy, amino, amine group, carboxyl, sulfonic acid group, ester group, acyloxy, amide, sulfonic acid ester group, sulfonamido, linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or aromatic fused heterocyclyl, wherein each of the linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or aromatic fused heterocyclyl may be independently substituted with one or more selected from the group consisting of halogen, cyano, hydroxyl, mercapto, ether group, nitro, alkoxy, amino, amine group, carboxyl, sulfonic acid group, ester group, amide, sulfonic acid ester group, sulfonamido, alkyl or haloalkyl;
• or R4 and R5 together form an oxo group;
• or, any two or three of R4, R5 and R6 together with the carbon atom to which L3 is attached form a cyclic group A to which L3 is attached:
• wherein the cyclic group A is any one selected from the group consisting of the following cyclic groups:
• aromatic ring group, saturated or unsaturated cycloalkyl, monoheterocyclyl, fused heterocyclyl, benzoheterocyclyl, spirocyclic group, bridged cyclic group and their cyclic groups substituted with R11;
• W is selected from the group consisting of hydrogen, H, alkyl, —CR8aR9aR10a, —NR8aR9a, —OR10a, or a carbon atom-containing cyclic group B1 that may be substituted with one or two or more R7 and is attached to a benzopyrone ring through the carbon atom:
• or a nitrogen atom-containing cyclic group B2 that is attached to a benzopyrone ring through the nitrogen atom:
• here, R8a, R9a and R10a are each independently selected from the group consisting of H, halogen, alkyl, cyano, hydroxyl, mercapto, ether group, nitro, alkoxy, amino, amine group, carboxyl, sulfonic acid group, ester group, acyloxy, amide, sulfonic acid ester group, sulfonamido, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or aromatic fused heterocyclyl;
• the cyclic group B1 and the cyclic group B2 are each independently selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
• wherein R7 is selected from the group consisting of H, halogen, —CN, —NO2, —OR8, —NR8R9, —SR8, —COR8, —SOR8, —SO2R8, —NR8COR9, —CONR8R9, —OCOR8, —COOR8, —OCONR8R9, —NR8CONR9R10, —NR8COOR9, —NR8SO2R9, —SO2NR8R9, —OSO2R8, —SO3R8, linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or aromatic fused heterocyclyl;
• or, R7 is selected from the group consisting of cyano, hydroxyl, mercapto, ether group, nitro, alkoxy, amino, amine group, carboxyl, sulfonic acid group, ester group, amide, acyloxy, sulfonic acid ester group and sulfonamido;
• wherein each of the linear alkyl, linear heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or aromatic fused heterocyclyl is independently substituted with one or two or more R11, and R8, R9 and R10 have the same meaning as R8, R9 and R10 present in R4, R5 and R6;
• and
• formula (I) does not comprise the following compound: