Novel 2-((trans-4-(4-aryloxy)cyclohexyl)amino)quinazolinone derivative and method for preparing same
AssigneesPusan National University Industry-University Cooperation Foundation, Kosin University Industry-Academy Cooperation
InventorsHwayoung YUN, Jee-Yeong JEONG, Jinsook KWAK, Min Jung KIM
Life of this patent
Estimating the term…
Abstract
The objective of the present invention is to provide a novel 2-((trans-4-(4-aryloxy)cyclohexyl)amino)quinazolinone derivative which exhibits anti-cancer activity through elF2α phosphorylation efficacy, wherein the novel synthesized derivative exhibits an eIF2α phosphorylation effect and cancer cell proliferation inhibitory activity in vitro, and thus can be used as a metabolic anti-cancer drug in pharmaceutical and health functional food compositions for preventing and ameliorating leukemia and other rare cancers such as breast cancer, brain tumor, and sarcoma.
Claims12
A compound selected from a 2-((trans-4-(4-aryloxy)cyclohexyl)amino)quinazolinone derivative compound represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a solvate thereof, or a stereoisomer thereof.
- In the Chemical Formula 1,
- R1 and R2 are the same or different and each selected from the group consisting of hydrogen (H), halogen, trifluoromethyl (CF3), nitro (NO2), (C1~C4)alkoxy, trifluoromethoxy (OCF3), cyano (CN), nitro (NO2), (C1~C4)alkylsulfonyl, and aminosulfonyl (SO2NH2).
- but 4-(((1,4-trans)-4-((4-oxo-7-(trifluoromethyl)-1,4-dihydroquinazolin-2-yl)amino)cyclohexyl)oxy)benzenesulfonamide is excluded.
11-13. (canceled)
Dependencies are inferred from the claim text.