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US 2026/0200849 A1Published application
Cationic lipids and preparation method thereof
AssigneeRiboX Therapeutics HK Limited
InventorsRoi Mashiach, Niv Cohen, Moshe Goldmeier, Aviad Sela, Fei Lin
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Abstract
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.
Claims11
1-39. (canceled)
A cationic lipid represented by the structure of formula (II):
- or a salt, hydrate, solvate, polymorph, optical isomer, geometrical isomer, enantiomer, diastereomer, tautomer, isotope labeled compound or mixtures thereof,
- wherein:
- L′ is —C1-6 alkylene-;
- X is O;
- Y is O;
- RH is NR4R5, wherein R4 and R5 together with the nitrogen to which they are attached form a 4- to 10-membered heterocyclic ring, optionally containing one or more additional heteroatoms selected from the group consisting of O, N and S;
- RT1 and RT2 are each independently selected from the group consisting of:
- (a) C10-C22 alkyl;
- (b) C10-C22 alkenyl;
- (c) C10-C22 alkynyl;
- (d) C4-C15 alkylene-Z—C4-C22 alkyl;
- and
- (e) C4-C15 alkylene-Z—C4-C22 alkenyl;
- Z is —O—C(═O)—, —C(═O)—O— or —O—.
11 more elements
Dependencies are inferred from the claim text.