Synthetic derivatives of oleoyl-lysophosphatidylinositol (oleoyl-lpi) and uses thereof
AssigneeLipovexa Srl
InventorsMarco Falasca, Massimiliano Massi, Peter Vernon Simpson
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Abstract
The invention relates to oleoyl-lysophosphatidylinositol (oleoyl-LPI) and new synthetic derivatives thereof and uses thereof, and to pharmaceutical compositions comprising such compounds. The invention provides activators and/or up-regulators of glucoregulatory hormones such as glucagon like peptide-1 (GLP-1), and more specifically to agonists, partial agonists and reverse antagonists of GPR119 or activators of GLP-1 activity and/or synthesis and/or secretion, and pharmaceutical compositions comprising same, uses thereof in therapy of diabetes, obesity and other metabolic disorders.
Claims26
A method of inducing and/or increasing secretion and/or synthesis and/or activity of GLP-1 in a cell, said method comprising contacting a cell comprising or secreting or capable of expressing or secreting GLP-1 with an effective amount of oleoyl-LPI or a salt or solvate thereof.
A method of agonizing and/or partially agonizing and/or reverse antagonizing GPR119 in a cell, comprising contacting a cell capable of expressing GPR119 with an effective amount of oleoyl-LPI or a salt or solvate thereof.
A method of treating or preventing a metabolic disorder in a subject in need thereof, said method comprising administering to the subject a therapeutically effective amount of oleoyl-LPI or a pharmaceutically acceptable salt or solvate thereof.
A method of treating or preventing a liver disorder in a subject in need thereof, said liver disorder selected from non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), fatty liver and liver fibrosis, said method comprising administering to the subject a therapeutically effective amount of oleoyl-LPI or a pharmaceutically acceptable salt or solvate thereof.
A functional food, nutraceutical, food supplement or dietary supplement comprising oleoyl-LPI and/or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.