Methods For Modulating Lymphatic Pathway of Central Nervous System
AssigneeFibralign Corporation
InventorsMichael Paukshto, Dimitrios Dionyssiou
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Abstract
In some embodiments herein, implantable scaffolds, their compositions, and methods for modulating lymphatic pathway in the central nervous system and in the vicinity of the central nervous system are presented. Modulating lymphatic pathway, increasing the flow and turnover of fluid in the central nervous system, and, in particular, inducing formation of new lymphatic vessels, in accordance with some embodiments, are used to treat, prevent, or ameliorate symptoms of neurodegenerative diseases.
Claims23
A method of increasing flow of fluid in the central nervous system of a subject in need thereof, the method comprising:
- implanting a biocompatible scaffold into the subject head or neck wherein the scaffold induces a directional lymphatic regeneration and formation of a complementary lymphatic pathway,
- thereby resulting in an additional flow of cerebrospinal and/or extracellular fluid from the central nervous system into the circulatory system of the subject.
A method of increasing turnover of cerebrospinal fluid of a subject in need thereof, the method comprising:
- implanting a biocompatible scaffold into the subject head or neck wherein the scaffold induces a directional lymphangiogenesis,
- thereby resulting in an increase in turnover of the subject cerebrospinal fluid.
Dependencies are inferred from the claim text.