Injectable compositions for treating joint conditions
AssigneeOhio State Innovation Foundation
InventorsKatelyn Elizabeth REILLY, Devina WALTER
Life of this patent
Estimating the term…
Abstract
Methods of treating joint conditions are described. In some implementation, the method includes injecting into an affected joint of the subject a therapeutically effective amount of a therapeutic composition which may include a hydrogel: and a second agent dispersed within the hydrogel selected from one or more antioxidants, one or more reactive oxygen species (ROS) scavengers, or combinations thereof. Injectable compositions useful in treating joint conditions are also provided.
Claims31
A method of treating a joint condition in a subject in need thereof, the method comprising
- injecting into an affected joint of the subject a therapeutically effective amount of a therapeutic composition comprising:
- a hydrogel;
- and
- a second agent dispersed within the hydrogel selected from one or more antioxidants, one or more reactive oxygen species (ROS) scavengers, or combinations thereof.
(canceled)
(canceled)
(canceled)
16-17. (canceled)
20-23. (canceled)
(canceled)
(canceled)
An injectable composition comprising:
- a hydrogel comprising one or more residues selected from poly(ethylene glycol)diacrylate (PEDGA), poly(ethylene glycol)methacrylate (PEGMA), 2-hydroxyethylmethacrylate (HEMA), or combinations thereof, and
- a reactive oxygen species (ROS) scavenger comprising a plurality of particles.
31-42. (canceled)
An injectable composition comprising:
- a hydrogel comprising a mixture or copolymer of a polyalkylene glycol and a second component selected from hyaluronate, fibrin, alginate, or collagen;
- and
- a second agent dispersed within the hydrogel selected from one or more antioxidants, one or more reactive oxygen species (ROS) scavengers, or combinations thereof.
44-62. (canceled)
A method of treating a joint condition in a subject in need thereof, the method comprising injecting into an affected joint of the subject a therapeutically effective amount of a therapeutic composition comprising:
- one or more reactive oxygen species (ROS) scavengers and one or more therapeutic agents.
64-76. (canceled)
Dependencies are inferred from the claim text.