Copper-based mof-modified small-diameter polyurethane vascular graft and preparation method therefor

Abstract

The present invention belongs to the technical field of biomedical composite materials, and discloses a copper-based MOF-modified small-diameter polyurethane vascular graft and a preparation method therefor. The present invention uses a copper-based metal organic framework as a functional carrier to be compounded with polyurethane, and uses electrospinning technology to prepare a vascular graft with an inner diameter of ≤6 mm, which achieves synergistic release of copper ions, nitric oxide and drug molecules. A preparation process includes the steps of copper-based metal organic framework synthesis, polyurethane solution preparation, drug loading, electrospinning molding, etc. The present invention innovatively constructs a synergistic system of “mechanical adaptation—biological regulation”, which effectively promotes the proliferation of endothelial cells while inhibiting the excessive proliferation of smooth muscle cells, and provides an ideal microenvironment for vascular repair. The present invention solves the clinical problems of mechanical property mismatch, thrombosis, endometrial hyperplasia, etc. of small-diameter vascular grafts.

Dependencies are inferred from the claim text.