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US 2026/0199532 A1Published application
Radiolabeled copper chelates and use thereof
AssigneeThe Trustees of Indiana University
InventorMark Alan Green
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Abstract
Disclosed herein are copper chelate compounds and their use in imaging methods, such as emission tomography (PET) imaging. The methods disclosed herein may be suitable for whole-body imaging.
Claims23
A compound of formula (I), or a pharmaceutically acceptable salt thereof,
- wherein
- (i) R1 is RA—O—(CH2)n and R11 is H or C1-6alkyl;
- or
- (ii) R1 and R11 together with the carbon atom they are attached to form a C3-6cycloalkyl;
- and
- R2, R3, R4, R5 are independently H or C1-6alkyl;
- RA is H or C1-6alkyl;
- n is 0, 1, 2, 3, 4, 5, or 6;
- and
- M is a copper isotope;
- provided that R1R11CH— is not Me(EtO)CH.
8 more elements
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A method of identifying tissue-specific distribution of a radiolabeled complex comprising a radiocopper in a subject, the method comprising imaging an excised tissue having the radiocopper therein.
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Dependencies are inferred from the claim text.