Engineered Plant Virus-Based Nanoparticles and Intravenous Formulations Thereof for Autoimmune Therapy

A kit for preparing an intravenous pharmaceutical composition for treatment or prevention of an autoimmune condition, comprising:

• i. a first container comprising a plant virus-based nanoparticle engineered to display a peptide associated with an autoimmune condition, provided in a liquid form in a physiological solution comprising sodium chloride and sorbitol;
• or
• ii. a first container comprising a plant virus-based nanoparticle engineered to display a peptide associated with an autoimmune condition, provided in a powder or lyophilized form;
• a second container comprising a delivery vehicle, comprising a physiological solution comprising sodium chloride and sorbitol;
• and
• a third container comprising a pharmaceutically acceptable buffer for reconstituting the plant virus-based nanoparticle and the delivery vehicle prior to intravenous administration;
• wherein the first container, second container, or third container is provided in a pre-filled syringe.