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OwnerHelena PERSSON LOTSHOLM, Sara MANGSBO +3inventors
InventorsHelena PERSSON LOTSHOLM, Sara MANGSBO, Oskar ANDERSSON, Johan ROCKBERG, Aman MEBRAHTU
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The present disclosure provides an improved binding molecule comprising an immunoglobulin binding domain, with affinity for a peptide tag moiety. The binding molecule is for example useful as a part of a bispecific conjugate. It exhibits unexpected benefits as part of a biopharmaceutical product, when compared to known binding molecules having a similar binding affinity. Also provided are bispecific conjugates comprising the binding molecule, and complexes comprising the bispecific conjugates non-covalently bound to a tag construct comprising a peptide tag moiety and a cargo moiety which comprises an antigen, for antigen delivery to immune cells. Medical uses of the binding molecules, conjugates and complexes of the disclosure are also provided.
A binding molecule, comprising:
Binding molecule according to any preceding claim, which is capable of selective binding to a peptidic tag moiety comprised in a tag construct, said tag construct optionally further comprising at least one cargo moiety.
A bispecific conjugate comprising:
Dependencies are inferred from the claim text.